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The main objective of the MRMC is to publish concise reviews on important developments in medicinal chemistry and related disciplines. Since the inaugural publication in May 2001, MRMC has gained a considerable stature in the field of medicinal chemistry and is now regarded as a very respectable review Journal (Impact Factor 3.06). The success of MRMC is based on the deep commitment of outstanding Regional Editors (RE), eminent contributors, committed administrative and technical staff and members of the Editorial Advisory Board (EAB). A flow of excellent manuscripts continue to be received, reviewed and published. In this Special Issue, contributions from a Regional Editor and our Editorial Advisory Board Members (5) are presented. Andreas Hilgeroth (EAB) (Martin-Luther University, Halle, Germany) and his colleague present a review of selective kinase inhibitors as potential anticancer drugs. They also note that since these drugs are relatively new, perhaps, potential sideeffects might be found in future extended usage. Georg Petroianu (EAB), United Arab Emirates University, Al Ain, UAR) and co-worker discuss reactivation of organic phosphorus cholinesterase inhibitors utilizing pyridinium oximes. Paula I. Moreira (EAB) (University of Coimbra, Coimbra, Portugal) and co-workers present an overview on the antihyperglycymic and clinical effects of metformin in the treatment of Type 2 diabetes. Hugo Cerecetto (EAB) (Dep. Quimica Organica, Montevideo, Uruguay) and his co-worker discuss the developments of new chemical entities for treatment of third world parasitic diseases, especially Chagas disease. Ross P. McGeary (RE) (The University of Queensland, Brisbane, Australia) and co-workers survey the applications of Suramin in the treatment of African river blindness and sleeping sickness and many types of cancers. George Perry (EAB) (College of Sciences, University of Texas at San Antonio) and collaborators discuss antioxidant therapy in the treatment of Alzheimer disease. We wish to acknowledge our colleagues for their excellent contribution and for their efforts in the preparation of the manuscripts.