Full text loading...
- ISSN: 1389-5575
- E-ISSN: 1875-5607
-
A Molecular Guidance System Based Upon Target Genes, Nuclear Receptors and Ligands Applied to Drug Discovery and Prediction of Toxicity
- Source: Mini Reviews in Medicinal Chemistry, Volume 8, Issue 12, Oct 2008, p. 1252 - 1264
-
- 01 Oct 2008
Abstract
A molecular guidance system useful in drug design is described in which nuclear receptors position ligands in intercalation sites in responsive genes. Evidence is based upon positions of agonists in receptors and the transcriptional activity of a designed estrogen that is 3 times more potent than the steroid hormone estradiol.
© Bentham Science Publishers