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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Molecular Structural Characteristics of Estrogen Receptor Modulators as Determinants of Estrogen Receptor Selectivity
- Source: Mini Reviews in Medicinal Chemistry, Volume 8, Issue 9, Aug 2008, p. 943 - 951
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- 01 Aug 2008
Abstract
This review will discuss the structural determinants and requirements necessary for estrogen receptors alpha and beta selectivity and ligand-receptor binding affinity. In addition, strategies likely to result in the development of a pharmacophore model that account for the differences in estrogenic effects between different ligands will be discussed.
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