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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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On The Edge of Validation - Cancer Protease Fibroblast Activation Protein
- Source: Mini Reviews in Medicinal Chemistry, Volume 8, Issue 7, Jun 2008, p. 719 - 727
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- 01 Jun 2008
Abstract
Numerous studies implicate the prolyl peptidase, fibroblast activation protein (FAP) in tumorigenesis; however, FAP-selective inhibitors have not yet been developed to fully validate FAP as a therapeutic target. Herein, we review recent efforts aimed at validating and inhibiting FAP for cancer therapy and highlight future directions for successful targeting of this prolyl peptidase.
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