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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Development of 11β -HSD1 Inhibitors for the Treatment of Type 2 Diabetes
- Source: Mini Reviews in Medicinal Chemistry, Volume 8, Issue 7, Jun 2008, p. 702 - 710
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- 01 Jun 2008
Abstract
Glucocorticoid action is linked to the development of obesity and insulin resistance. Inhibition of 11β- hydroxysteroid dehydrogenase type 1 (11β-HSD1) has been proposed as a strategy to suppress glucocorticoid action in a tissue-specific manner. A large variety of 11β-HSD1 inhibitor classes are under investigation by the pharmaceutical industry to treat type 2 diabetes and obesity.
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