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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Fondaparinux: Pharmacology and Clinical Experience in Cardiovascular Medicine
- Source: Mini Reviews in Medicinal Chemistry, Volume 7, Issue 4, Apr 2007, p. 383 - 387
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- 01 Apr 2007
Abstract
Fondaparinux is a synthetic, five-saccharide chain, AT-dependent, anti-FXa agent. Studies showed that fondaparinux acts in prevention and treatment of venous thromboembolism and in ischemic heart disease, without significant bleeding risk. The drug inhibits thrombin generation, has long half-life and can be administered once-daily without laboratory monitoring. It may be used in HIT treatment.
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