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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Pharmacophore Identification: The Case of the Ser/Thr Protein Phosphatase Inhibitors
- Source: Mini Reviews in Medicinal Chemistry, Volume 6, Issue 6, Jun 2006, p. 657 - 665
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- 01 Jun 2006
Abstract
This review provides a chronological account of the identification and refinement of the pharmacophore for inhibition of two key serine/threonine protein phosphatases, PP1 and PP2A. The dramatic impact of natural product isolation, molecular modeling, analogue design, biochemical studies, and crystallography on the evolution of the pharmacophore will be described.
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