Functional Chemokine Receptors in Allergic Diseases: Is CCR8 a Novel Therapeutic Target?

E. Mitsuyama; Y. Kunori; T. Kamimura; O. Kaminuma

doi:10.2174/138955706776361394

ISSN: 1389-5575
E-ISSN: 1875-5607

Functional Chemokine Receptors in Allergic Diseases: Is CCR8 a Novel Therapeutic Target?
Authors: E. Mitsuyama¹, Y. Kunori², T. Kamimura³ and O. Kaminuma⁴
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¹ Cytokine Project, The Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan. ² Cytokine Project, The Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan. ³ Cytokine Project, The Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan. ⁴ Cytokine Project, The Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan.
Source: Mini Reviews in Medicinal Chemistry, Volume 6, Issue 4, Apr 2006, p. 463 - 466
DOI: https://doi.org/10.2174/138955706776361394
- Available online: 01 Apr 2006

Abstract

CC chemokine receptor (CCR) 8, which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. This review represents an overview of the functional roles of CCR8 in the pathogenesis of eosinophilic inflammation and debates the potential of recently developed CCR8 antagonists to treat allergic disorders.

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2006-04-01

2025-09-10

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Article Type: Research Article

Keyword(s): Allergy; atopic dermatitis; bronchial asthma; chemokine; eosinophil; knockout mouse; Th2 cell

Functional Chemokine Receptors in Allergic Diseases: Is CCR8 a Novel Therapeutic Target?

Abstract

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