1,2,4,5-Tetraoxacycloalkanes: Synthesis and Antimalarial Activity

A. Masuyama; J.- M. Wu; M. Nojima; H.- S. Kim; Y. Wataya

doi:10.2174/138955705774575255

ISSN: 1389-5575
E-ISSN: 1875-5607

1,2,4,5-Tetraoxacycloalkanes: Synthesis and Antimalarial Activity
Authors: A. Masuyama¹, J.- M. Wu², M. Nojima³, H.- S. Kim⁴ and Y. Wataya⁵
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¹ Department of Materials Chemistry, Graduate School of Engineering, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan. ² Department of Materials Chemistry, Graduate School of Engineering, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan. ³ Department of Materials Chemistry, Graduate School of Engineering, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan. ⁴ Department of Materials Chemistry, Graduate School of Engineering, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan. ⁵ Department of Materials Chemistry, Graduate School of Engineering, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan.
Source: Mini Reviews in Medicinal Chemistry, Volume 5, Issue 11, Nov 2005, p. 1035 - 1043
DOI: https://doi.org/10.2174/138955705774575255
- Available online: 01 Nov 2005

Abstract

In this short review the methods of preparation of novel 1,2,4,5-tetraoxacycloalkanes and the related peroxides are summarized, with the emphasis on the usefulness of 1,1-bishydroperoxides as the precursor. Also, their antimalarial activities in vitro and in vivo are discussed.

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2005-11-01

2025-09-03

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Article Type: Review Article

Keyword(s): 1,2,4,5-tetraoxacycloalkanes; 1,2,5,6-tetraoxacycloalkanes; 1,2,6,7-tetraoxaspiro[7.11]nonadecane; antimalarial activity; cyclization methods; medium-sized cyclic peroxides; p. berghei; p. falciparum

1,2,4,5-Tetraoxacycloalkanes: Synthesis and Antimalarial Activity

Abstract

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