Albumin Nanoparticles for the Intravitreal Delivery of Anticytomegaloviral Drugs

J. M. Irache; M. Merodio; A. Arnedo; M. A. Camapanero; M. Mirshahi; S. Espuelas

doi:10.2174/1389557053175335

ISSN: 1389-5575
E-ISSN: 1875-5607

Albumin Nanoparticles for the Intravitreal Delivery of Anticytomegaloviral Drugs
Authors: J. M. Irache¹, M. Merodio², A. Arnedo³, M. A. Camapanero⁴, M. Mirshahi⁵ and S. Espuelas⁶
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¹ Centro Galenico, Department of Pharmaceutical Tecnology, University of Navarra, Ap. 177, Irunlarrea, 1, 31008 Pamplona, Spain. ² Centro Galenico, Department of Pharmaceutical Tecnology, University of Navarra, Ap. 177, Irunlarrea, 1, 31008 Pamplona, Spain. ³ Centro Galenico, Department of Pharmaceutical Tecnology, University of Navarra, Ap. 177, Irunlarrea, 1, 31008 Pamplona, Spain. ⁴ Centro Galenico, Department of Pharmaceutical Tecnology, University of Navarra, Ap. 177, Irunlarrea, 1, 31008 Pamplona, Spain. ⁵ Centro Galenico, Department of Pharmaceutical Tecnology, University of Navarra, Ap. 177, Irunlarrea, 1, 31008 Pamplona, Spain. ⁶ Centro Galenico, Department of Pharmaceutical Tecnology, University of Navarra, Ap. 177, Irunlarrea, 1, 31008 Pamplona, Spain.
Source: Mini Reviews in Medicinal Chemistry, Volume 5, Issue 3, Mar 2005, p. 293 - 305
DOI: https://doi.org/10.2174/1389557053175335
- Available online: 01 Mar 2005

Abstract

Albumin nanoparticles (NP) were proved to be effective and safe carriers for delivering anticytomegaloviral compounds in the vitreous. NP improved the antiviral activity of both ganciclovir and the phosphodiester oligonucleotide analog to formivirsen. NP appeared to be fusogenic carriers able to target the nucleus of cells. In addition, these drug carriers were well tolerated when administered by the intravitreal route and did not induce autoimmune reactions.

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2005-03-01

2025-09-05

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Article Type: Review Article

Keyword(s): albumin; fomivirsen; ganciclovir; intravitreal delivery; nanoparticles; oligonucleotides; retinitis

Albumin Nanoparticles for the Intravitreal Delivery of Anticytomegaloviral Drugs

Abstract

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