“Lock-in”-cycloSal-Pronucleotides - A New Generation of Chemical Trojan Horses?

The cycloSal-concept is one example of a successful nucleotide delivering system (pronucleotide). For several nucleoside analogues, the cycloSal-approach improved the antiviral potency and the applicability of the nucleosides could be broadened. Here, a conceptional extension of the original design of the cycloSalsystem will be discussed.