The Role of Thymidine Kinases in the Activation of Pyrimidine Nucleoside Analogues

Ashraf S. Al-Madhoun; Werner Tjarks; Staffan Eriksson

doi:10.2174/1389557043403963

ISSN: 1389-5575
E-ISSN: 1875-5607

The Role of Thymidine Kinases in the Activation of Pyrimidine Nucleoside Analogues
Authors: Ashraf S. Al-Madhoun¹, Werner Tjarks² and Staffan Eriksson³
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¹ Department of Molecular Biosciences, Division of Veterinary Medical Bio-Chemistry, Swedish University of Agricultural Sciences, The Biomedical Center, Box 575, S-751 23 Uppsala, Sweden. ² Department of Molecular Biosciences, Division of Veterinary Medical Bio-Chemistry, Swedish University of Agricultural Sciences, The Biomedical Center, Box 575, S-751 23 Uppsala, Sweden. ³ Department of Molecular Biosciences, Division of Veterinary Medical Bio-Chemistry, Swedish University of Agricultural Sciences, The Biomedical Center, Box 575, S-751 23 Uppsala, Sweden.
Source: Mini Reviews in Medicinal Chemistry, Volume 4, Issue 4, May 2004, p. 341 - 350
DOI: https://doi.org/10.2174/1389557043403963
- Available online: 01 May 2004

Abstract

Deoxynucleoside analogues need activation by deoxynucleoside kinases to serve as antiviral or anticancer agents. Here we review the properties of cellular cytoplasmic thymidine kinase 1, mitochondrial thymidine kinase 2, the multisubstrate deoxynucleoside kinase from Drosophila melanogaster and Herpes virus 1 thymidine kinase. Important substrate activity relationships will be discussed.

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2004-05-01

2025-12-09

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Article Type: Review Article

Keyword(s): bnct; chemotherapy; hsv1-tk; nucleoside analogues; tk1; tk2 dm-dnk

The Role of Thymidine Kinases in the Activation of Pyrimidine Nucleoside Analogues

Abstract

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