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2000
Volume 4, Issue 5
  • ISSN: 1389-5575
  • E-ISSN: 1875-5607

Abstract

To catalytically-modify ribosomes in vivo, ribosome-inactivating proteins produced by plants must enter susceptible mammalian cells in order to reach their substrates in the cytosol. This review primarily focuses on the biosynthesis, mechanism of cell entry and intracellular trafficking of ricin, the most thoroughly studied ribosome-inactivating protein in this respect.

© Bentham Science Publishers
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/content/journals/mrmc/10.2174/1389557043403846
2004-06-01
2025-09-11

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  • Article Type:     Review Article
Keyword(s): depurination; endoplasmic reticulum; retograde transport; retro-translocation; ribosome; ricin

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