First and Second Generations of COX-2 Selective Inhibitors

Xavier d. Leval; Fabien Julemont; Valerie Benoit; Michel Frederich; Bernard Pirotte; Jean-Michel Dogne

doi:10.2174/1389557043403693

ISSN: 1389-5575
E-ISSN: 1875-5607

First and Second Generations of COX-2 Selective Inhibitors
Authors: Xavier d. Leval¹, Fabien Julemont², Valerie Benoit³, Michel Frederich⁴, Bernard Pirotte⁵ and Jean-Michel Dogne⁶
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¹ University of Liege, Natural and Synthetic Drugs, Research Center, Department of Medicinal Chemistry, 1, avenue de l'Hopital, tour 4(+5), B-4000 Liege (Belgium) ² University of Liege, Natural and Synthetic Drugs, Research Center, Department of Medicinal Chemistry, 1, avenue de l'Hopital, tour 4(+5), B-4000 Liege (Belgium) ³ University of Liege, Natural and Synthetic Drugs, Research Center, Department of Medicinal Chemistry, 1, avenue de l'Hopital, tour 4(+5), B-4000 Liege (Belgium) ⁴ University of Liege, Natural and Synthetic Drugs, Research Center, Department of Medicinal Chemistry, 1, avenue de l'Hopital, tour 4(+5), B-4000 Liege (Belgium) ⁵ University of Liege, Natural and Synthetic Drugs, Research Center, Department of Medicinal Chemistry, 1, avenue de l'Hopital, tour 4(+5), B-4000 Liege (Belgium) ⁶ University of Liege, Natural and Synthetic Drugs, Research Center, Department of Medicinal Chemistry, 1, avenue de l'Hopital, tour 4(+5), B-4000 Liege (Belgium)
Source: Mini Reviews in Medicinal Chemistry, Volume 4, Issue 6, Aug 2004, p. 597 - 601
DOI: https://doi.org/10.2174/1389557043403693
- Available online: 01 Aug 2004

Abstract

The identification and characterization of the inducible form of cyclooxygenases (COX-2) stimulated the investigations to develop efficient, non-steroidal anti-inflammatory drugs (NSAIDs) with reduced side effects (essentially gastro-intestinal toxicity) compared to classical NSAIDs. This review focuses on the chemical and pharmacological properties (pre-clinical data) of marketed COX-2 inhibitors.

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2004-08-01

2025-11-03

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Article Type: Review Article

Keyword(s): cox-2 inhibitors; cox-2 selectivity; pre-clinical data

First and Second Generations of COX-2 Selective Inhibitors

Abstract

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