New Developments on Thromboxane Modulators

Jean-Michel Dogne; Julien Hanson; Xavier d. Leval; Bernard Masereel; Philippe Kolh; Bernard Pirotte

doi:10.2174/1389557043403684

ISSN: 1389-5575
E-ISSN: 1875-5607

New Developments on Thromboxane Modulators
Authors: Jean-Michel Dogne¹, Julien Hanson², Xavier d. Leval³, Bernard Masereel⁴, Philippe Kolh⁵ and Bernard Pirotte⁶
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¹ Natural and Synthetic Drug Research Centre, Medicinal Chemistry, University of Liège, 1, av. de l'Hôpital, B-4000 Liège, Belgium ² Natural and Synthetic Drug Research Centre, Medicinal Chemistry, University of Liège, 1, av. de l'Hôpital, B-4000 Liège, Belgium ³ Natural and Synthetic Drug Research Centre, Medicinal Chemistry, University of Liège, 1, av. de l'Hôpital, B-4000 Liège, Belgium ⁴ Natural and Synthetic Drug Research Centre, Medicinal Chemistry, University of Liège, 1, av. de l'Hôpital, B-4000 Liège, Belgium ⁵ Natural and Synthetic Drug Research Centre, Medicinal Chemistry, University of Liège, 1, av. de l'Hôpital, B-4000 Liège, Belgium ⁶ Natural and Synthetic Drug Research Centre, Medicinal Chemistry, University of Liège, 1, av. de l'Hôpital, B-4000 Liège, Belgium
Source: Mini Reviews in Medicinal Chemistry, Volume 4, Issue 6, Aug 2004, p. 649 - 657
DOI: https://doi.org/10.2174/1389557043403684
- Available online: 01 Aug 2004

Abstract

Thromboxane A2 (TXA2) is a labile product formed from arachidonic acid by cyclooxygenase. The pathogenesis of numerous cardiovascular, pulmonary, and thromboembolic diseases can be related to this metabolite. Therefore, TXA2 modulators have been developed for 20 years. This review will highlight the evolution in the field of TXA2 modulators.

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2004-08-01

2025-09-11

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Article Type: Review Article

Keyword(s): arachidonic acid; prostanoids; thromboxane a2; thromboxane synthase

New Developments on Thromboxane Modulators

Abstract

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