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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Inhibitors of Platelets Glycoprotein IIb / IIIa (GP IIb / IIIa) Receptor: Rationale for their Use in Clinical Cardiology
- Source: Mini Reviews in Medicinal Chemistry, Volume 4, Issue 7, Sep 2004, p. 703 - 709
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- 01 Sep 2004
Abstract
The glycoprotein IIb / IIIa (GP IIb / IIIa) receptor is the most important receptor involved in platelet aggregation. A stable GP IIb / IIIa inhibition is required when a massive platelet activation triggers thrombosis. Three GP IIb / IIIa inhibitors are currently approved for clinical use: abciximab, tirofiban and integrilin. Their different pharmacodynamic and pharmacokinetic properties reflect a different efficacy in platelet inhibition.
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