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2000
Volume 4, Issue 8
  • ISSN: 1389-5575
  • E-ISSN: 1875-5607

Abstract

Excessive hepatic glucose production is thought to be a major contributor to the type 2 diabetic state. Drug discovery efforts have yielded small synthetic inhibitors for gluconeogenic and glycogenic regulators of this pathway. The most advanced targets are outlined in this mini-review and include: the glucocorticoid receptor, 11β-hydroxysteroid dehydrogenase type 1, fructose 1,6-bisphosphatase, the glucagon receptor, glycogen phosphorylase, glycogen synthase kinase-3, and glucose-6-phosphatase.

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/content/journals/mrmc/10.2174/1389557043403459
2004-10-01
2025-09-10
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