Medicinal Chemistry and Biological Properties of Non-Imidazole Histamine H3 Antagonists

Marlon Cowart; Robert Altenbach; Lawrence Black; Ramin Faghih; Chen Zhao; Arthur A. Hancock

doi:10.2174/1389557043403215

ISSN: 1389-5575
E-ISSN: 1875-5607

Medicinal Chemistry and Biological Properties of Non-Imidazole Histamine H3 Antagonists
Authors: Marlon Cowart¹, Robert Altenbach², Lawrence Black³, Ramin Faghih⁴, Chen Zhao⁵ and Arthur A. Hancock⁶
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¹ Department of Neuroscience Research, GPRD R4MN, Abbott Labs, AP9a 216, Abbott Park, IL 60073-6123, USA. ² Department of Neuroscience Research, GPRD R4MN, Abbott Labs, AP9a 216, Abbott Park, IL 60073-6123, USA. ³ Department of Neuroscience Research, GPRD R4MN, Abbott Labs, AP9a 216, Abbott Park, IL 60073-6123, USA. ⁴ Department of Neuroscience Research, GPRD R4MN, Abbott Labs, AP9a 216, Abbott Park, IL 60073-6123, USA. ⁵ Department of Neuroscience Research, GPRD R4MN, Abbott Labs, AP9a 216, Abbott Park, IL 60073-6123, USA. ⁶ Department of Neuroscience Research, GPRD R4MN, Abbott Labs, AP9a 216, Abbott Park, IL 60073-6123, USA.
Source: Mini Reviews in Medicinal Chemistry, Volume 4, Issue 9, Nov 2004, p. 979 - 992
DOI: https://doi.org/10.2174/1389557043403215
- Available online: 01 Nov 2004

Abstract

The H3 receptor is prominently expressed in neuronal tissues, and H3 antagonists have been proposed as drugs with benefits in disorders of cognition, attention, pain, allergic rhinitis, and obesity. The structure-activity relationships (SAR) of various classes of non-imidazole H3 antagonists are reviewed, along with highlights of functional efficacy in tissue-based and animal disease models.

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2004-11-01

2025-12-07

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Article Type: Review Article

Keyword(s): antagonist; h3; histamine; inverse agonist; non-nimidazole; review

Medicinal Chemistry and Biological Properties of Non-Imidazole Histamine H3 Antagonists

Abstract

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