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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Biological Activity of Some Monocyclic- and Bicyclic β-Lactams with Specified Functional Groups
- Source: Mini Reviews in Medicinal Chemistry, Volume 3, Issue 4, Jun 2003, p. 305 - 313
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- 01 Jun 2003
Abstract
This Review contains our recent studies on evaluation of biological activities associated with monocyclic β-lactams and bicyclic β-lactam antibiotics containing various heteroatoms. A series of bicyclic β-lactams was synthesized, which possessed electron-withdrawing groups, such as an ester, mesylate, and triflate functionality. These β-lactams exhibited enhanced antibacterial activity.
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