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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Crystallography of Membrane Proteins, Major Targets in Drug Design
- Source: Mini Reviews in Medicinal Chemistry, Volume 3, Issue 5, Aug 2003, p. 439 - 448
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- 01 Aug 2003
Abstract
Protein crystallography has the potential to accelerate drug discovery greatly. High-resolution structures of membrane proteins of pharmaceutical interest open new perspectives in drug design. Recent structural data obtained for cyclooxygenases, monoamine oxidase, squalene cyclase, rhodopsine, porins, aquaporins, and ABC transporters are presented and briefly discussed.
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