Marine Natural Products as Lead Anti-HIV Agents

D. J. Gochfeld; K. A. El Sayed; M. Yousaf; J. F. Hu; P. Bartyzel; D. C. Dunbar; S. P. Wilkins; J. K. Zjawiony; R. F. Schinazi; S. Schlueter Wirtz

doi:10.2174/1389557033487962

ISSN: 1389-5575
E-ISSN: 1875-5607

Marine Natural Products as Lead Anti-HIV Agents
Authors: D. J. Gochfeld¹, K. A. El Sayed², M. Yousaf³, J. F. Hu⁴, P. Bartyzel⁵, D. C. Dunbar⁶, S. P. Wilkins⁷, J. K. Zjawiony⁸, R. F. Schinazi⁹ and S. Schlueter Wirtz¹⁰
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¹ Department of Pharmacognosy, School of Pharmacy, P.O. Box 1848, The University of Mississippi, University, MS 38677, USA. ² Department of Pharmacognosy, School of Pharmacy, P.O. Box 1848, The University of Mississippi, University, MS 38677, USA. ³ Department of Pharmacognosy, School of Pharmacy, P.O. Box 1848, The University of Mississippi, University, MS 38677, USA. ⁴ Department of Pharmacognosy, School of Pharmacy, P.O. Box 1848, The University of Mississippi, University, MS 38677, USA. ⁵ Department of Pharmacognosy, School of Pharmacy, P.O. Box 1848, The University of Mississippi, University, MS 38677, USA. ⁶ Department of Pharmacognosy, School of Pharmacy, P.O. Box 1848, The University of Mississippi, University, MS 38677, USA. ⁷ Department of Pharmacognosy, School of Pharmacy, P.O. Box 1848, The University of Mississippi, University, MS 38677, USA. ⁸ Department of Pharmacognosy, School of Pharmacy, P.O. Box 1848, The University of Mississippi, University, MS 38677, USA. ⁹ Department of Pharmacognosy, School of Pharmacy, P.O. Box 1848, The University of Mississippi, University, MS 38677, USA. ¹⁰ Department of Pharmacognosy, School of Pharmacy, P.O. Box 1848, The University of Mississippi, University, MS 38677, USA.
Source: Mini Reviews in Medicinal Chemistry, Volume 3, Issue 5, Aug 2003, p. 401 - 424
DOI: https://doi.org/10.2174/1389557033487962
- Available online: 01 Aug 2003

Abstract

Current anti-HIV drugs have extreme side effects and resistance to these drugs develops rapidly. The marine environment holds an unprecedented number of unusual chemical structural classes with activity against HIV. We review the literature on anti-HIV activity of marine natural products and discuss the efficacy of different structural classes.

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2003-08-01

2025-09-12

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Article Type: Review Article

Keyword(s): aids; alkaloids; hiv; marine natural products; modified peptides; structure-activity relationships

Marine Natural Products as Lead Anti-HIV Agents

Abstract

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