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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Molecular Pharmacophore Determination of Lipid Lowering Drugs with the Receptor Mapping Method
- Source: Mini Reviews in Medicinal Chemistry, Volume 2, Issue 2, Apr 2002, p. 97 - 102
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- 01 Apr 2002
Abstract
Hypolipidemic pharmacophoric moieties of statins, fibrates, ACAT inhibitors and beta-sitosterol analog series were identified by computational modeling, and compared with the computed structure of new potential glycyrrhetinic acid derivatives lipid-lowering drugs. Their electronic and geometric domains, similar to those of fibrates, suggest a fibrate -like mechanism matching biochemical data.
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