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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Structure-activity Relationship, Conformation and Pharmacology Studies of Morphiceptin Analogues - Selective μ-Opioid Receptor Ligands
- Source: Mini Reviews in Medicinal Chemistry, Volume 2, Issue 6, Dec 2002, p. 565 - 572
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- 01 Dec 2002
Abstract
Morphiceptin (Tyr-Pro-Phe-Pro-NH2) is one of the most selective agonists for the μ-opioid receptor. In this review structure-activity relationships of morphiceptin analogues and studies resulting in defining low energy conformations are discussed. Finally, new developments in the control of tumour growth and cell proliferation by morphiceptin analogues are surveyed, which open future perspectives in the diagnosis and treatment of various cancers.
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