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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Recent Advances in Topoisomerase I-Targeting Agents, Camptothecin Analogues
- Source: Mini Reviews in Medicinal Chemistry, Volume 2, Issue 6, Dec 2002, p. 611 - 619
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- 01 Dec 2002
Abstract
The present review concentrates on camptothecin (CPT) analogues, the most extensively studied topoisomerase I (topo I) inhibitors, and provides concise information on the structural features of human topo I enzyme, mechanisms of interaction of CPT with topo I, structure-activity relationship study of CPT analogues including the influence of lactone stability on antitumor activity, and recent updates of valuable CPT analogues.
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