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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Antibody Directed Enzyme Prodrug Therapy (ADEPT) and Related Approaches for Anticancer Therapy
- Source: Mini Reviews in Medicinal Chemistry, Volume 1, Issue 4, Nov 2001, p. 399 - 407
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- 01 Nov 2001
Abstract
In antibody directed enzyme prodrug therapy (ADEPT) an antibody bound enzyme is targeted to tumor cells. This allows for selective activation of a nontoxic prodrug to a cytotoxic agent at the tumor site for cancer therapy. Site-selective prodrug activation results in reduced side effects in remote tissue. This article reviews ADEPT with emphasis on the chemical viewpoint and recent developments.
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