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2000
Volume 25, Issue 20
  • ISSN: 1389-5575
  • E-ISSN: 1875-5607

Abstract

As the main fermentation product of (), fumagillin is directly related to the gene of and exhibits a variety of biological activities. However, its clinical application is limited by low yield and toxicity. It is of great significance to improve the yield and safety of fumagillin using . Currently, research on fumagillin at home and abroad primarily focuses on a single direction and lacks a systematic review of its biosynthesis, structure-activity relationship, and strain modification technology, as well as a comprehensive theoretical framework. This study systematically reviews the biosynthesis mechanism, activity characteristics, and targeted strain modification technology of fumagillin, providing theoretical support for breakthroughs in production, toxicity regulation, and clinical transformation of fumagillin.

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2026-03-01

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/content/journals/mrmc/10.2174/0113895575377839251007060804
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Research Progress in Mutagenesis Techniques for Aspergillus fumigatus and the Biological Activities of Fumagillin
Mini Rev Med Chem 25, 1588 (2025); https://doi.org/10.2174/0113895575377839251007060804
/content/journals/mrmc/10.2174/0113895575377839251007060804
/content/journals/mrmc/10.2174/0113895575377839251007060804
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  • Article Type:     Review Article
Keyword(s): Aspergillus fumigatus; biological activity; fermentation; fumagillin; genetic engineering; mutagenesis breeding

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