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2000
Volume 25, Issue 6
  • ISSN: 1389-5575
  • E-ISSN: 1875-5607
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Abstract

Organic compounds containing azines, di-imines, or -Schiff-bases have two azomethine (-CH=N-) functional groups associated with a bridging component. These constituents have attracted attention from a diversity of disciplines, comprising coordination, medicinal, agriculture chemistry, and organic synthesis, because of their comprehensive chemical reactivity and nature. This study determines common synthetic approaches and various biological and pharmacological activities of several substituted -Schiff byproducts. The usefulness of -Schiff bases in synthetic chemistry and their potential as inhibitors of a number of enzymes have attracted research attention. We have examined different biological activities and common synthetic methods used to make -Schiff bases that have been published in the literature. A systematic search of the literature has been performed, and studies fitting the prearranged inclusion standards have been inspected. This review can open up new potentials for upcoming research in this area and advance our information on -Schiff bases.

© 2025 The Author(s). Published by Bentham Science Publisher.
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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/content/journals/mrmc/10.2174/0113895575363243241129100845
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Exploring the Versatility of Azine Derivatives: A Comprehensive Review on Synthesis and Biological Applications
Mini Rev Med Chem 25, 425 (2025); https://doi.org/10.2174/0113895575363243241129100845
/content/journals/mrmc/10.2174/0113895575363243241129100845
/content/journals/mrmc/10.2174/0113895575363243241129100845
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  • Article Type:     Review Article
Keyword(s): azines; biological activities; bis-Schiff bases; di-imines; enzyme inhibitions; Synthesis

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