Lab-on-Chip for Pharmacogenomics: An Embedded System Organization

This paper presents the architecture of the electronic detection and data processing (analysis) part, of a Lab-on- Chip (LoC) device. The data processing part focuses on the analysis of signals captured from the sensors used to detect possible mutations in the sample under consideration. The LoC consists of a micro-fluidics part for the sample preparation and hybridization, a micro-system part including the sensors for the hybridization electronic detection and finally a processing part for the data analysis and an interface for results presentation. The use of such LoCs aims at identifying the appropriate cluster of patients for a pharmacogenomic medicine based on the gene analysis results and at optimizing the effectiveness of the drug or determining whether the affected patient belongs to a group of patients who would suffer severe side effects.