Effect of Solvents, Drug/Polymer Ratio and Surfactant Concentration on In Vitro Characteristic of Repaglinide Loaded Poly (Meth) Acrylate Nanoparticles

In the present work Repaglinide loaded ammonio methacrylate copolymer nanoparticles were developed by modified solvent emulsion technique using high pressure homogenizer. An effect of numerous organic solvents, surfactant concentration, drug-polymer ratios and combination of polymers on encapsulation efficiency as well as drug release profile were studied. Sustained released nanoparticles were obtained in the size of less than 400 nm. FE-SEM showed smooth and rigid surface of Eudragit RS nanoparticle’s while porous surface nature was observed in Eudragit RL nanoparticles. No drug-polymer interaction was found. X-RD revealed that the crystallinity of repaglinide was decreased when processed with Eudragit polymers. Eudragit RSPO retained drug for more time than other copolymers. Most of the formulations followed zero order kinetics. Prepared nanoparticles can be used for the treatment of type 2 diabetes mellitus by minimizing dose rate, reducing adverse effects and enhancing patient fulfillment.