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- ISSN: 1573-4064
- E-ISSN: 1875-6638
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Inhibitory Feature of the Proprotein Convertases Prosegments
- Source: Medicinal Chemistry, Volume 4, Issue 2, Mar 2008, p. 116 - 120
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- 01 Mar 2008
Abstract
The proprotein convertases (PCs) are serine proteases involved in various physiological processes and their overactivity or inactivity has been linked to different disorders. PCs are responsible for the proteolytic processing of various polypeptide precursors. Here, we discuss the effect of their N-terminal prosegments on various PC substrates processing and functions.
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