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- ISSN: 1573-4064
- E-ISSN: 1875-6638
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Studies on the Structure-Activity Relationship of the Basic Amine of Phenylpiperazines as Melanocortin-4 Receptor Antagonists
- Source: Medicinal Chemistry, Volume 4, Issue 1, Jan 2008, p. 67 - 74
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- 01 Jan 2008
Abstract
A series of piperazinephenethylamines were synthesized to study the contribution of a basic amine to binding affinity at the melanocortin-4 receptor. Several potent compounds from this series possessed subnanomolar Ki values in a competition binding assay.
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