In Search of New Cures for Tuberculosis

Marina Protopopova; Elena Bogatcheva; Boris Nikonenko; Sam Hundert; Leo Einck; Carol A. Nacy

doi:10.2174/157340607780620626

ISSN: 1573-4064
E-ISSN: 1875-6638

In Search of New Cures for Tuberculosis
Authors: Marina Protopopova¹, Elena Bogatcheva², Boris Nikonenko³, Sam Hundert⁴, Leo Einck⁵ and Carol A. Nacy⁶
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¹ Sequella, Inc., 9610 Medical Center Drive, Suite 200, Rockville, MD 20850, USA. ² Sequella, Inc., 9610 Medical Center Drive, Suite 200, Rockville, MD 20850, USA. ³ Sequella, Inc., 9610 Medical Center Drive, Suite 200, Rockville, MD 20850, USA. ⁴ Sequella, Inc., 9610 Medical Center Drive, Suite 200, Rockville, MD 20850, USA. ⁵ Sequella, Inc., 9610 Medical Center Drive, Suite 200, Rockville, MD 20850, USA. ⁶ Sequella, Inc., 9610 Medical Center Drive, Suite 200, Rockville, MD 20850, USA.
Source: Medicinal Chemistry, Volume 3, Issue 3, May 2007, p. 301 - 316
DOI: https://doi.org/10.2174/157340607780620626
- Available online: 01 May 2007

Abstract

The last 10 years have seen resurgent industry activity in discovery and development of new drugs for the treatment of tuberculosis (TB), a growing widespread and devastating (more than 2 million deaths annually) bacterial infection that is of increasing concern in developing and developed nations alike. This review describes drugs currently being evaluated in the clinic for treatment of uncomplicated and drug resistant pulmonary TB, and updates the literature on 5 new drugs that entered clinical trials in the last 4 years.

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2007-05-01

2025-10-31

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Article Type: Research Article

Keyword(s): BACTEC growth assay; drug resistant M. tuberculosis; fluoroquinolone; HIV therapy; PA-824

In Search of New Cures for Tuberculosis

Abstract

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