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- ISSN: 1573-4064
- E-ISSN: 1875-6638
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New Features in Synthesis of Talampanel Related 2,3-Benzodiazepines
- Source: Medicinal Chemistry, Volume 1, Issue 5, Sep 2005, p. 481 - 485
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- 01 Sep 2005
Abstract
Analogues of talampanel (1), a highly active AMPA antagonist 2,3-benzodiazepine, were synthesized, where the characteristic amino-function was either transposed or sterically shielded. For the key intermediates (hemiketals 6a, b) a new synthetic method of different mechanism was developed. The inactivity of several new compounds indicates the significance of the 4-amino(phenyl) function in BDZs of type 1.
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