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The field of medicinal chemistry has continued to expand rapidly, specially with the growing understanding of disease processes at the molecular level. This first issue of “Medicinal Chemistry” presents papers on recent advances in this field written by eminent experts. The articles on novel anti-malarials, anti-cancer agents, enzyme kinetics, sigma receptor binding SARS-cov genome sequences, apoptosis, lactoferrin interactions, immunotoxins and protease inhibitors should prove to be of considerable interest to researchers as well as the general community of medicinal chemists. It is hoped that “Medicinal Chemistry” would soon become an indispensable journal in this field.