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2000
Volume 4, Issue 1
  • ISSN: 2666-2906
  • E-ISSN: 2666-2914

Abstract

The long-term health implications of COVID-19 have posed a new challenge in clinical management, especially with the appearance of long COVID syndrome. Most of the attention has been on respiratory and neurological sequelae, but its impact on GI health is underexplored. It has been observed that abnormalities detected during the acute phase of SARS-CoV-2 infection can be used to predict potential post-acute sequelae within the digestive system. These anomalies are accompanied by immune dysregulation, cytokine storms, and damage to hepatocytes, resulting in fatigue, loss of appetite, and nutritional deficiencies persisting for several months and, therefore, significantly worsen recovery and quality of life. This current letter addresses the pertinent interaction between liver dysfunction and GI symptoms in the context of long COVID, highlighting the urgent need for early detection and personalized therapies in predisposed patients. It also examines the influence of vaccination, metabolic health, and early nutrition supplementation on the development and progression of these sequelae. Recent research emphasizes the increasing importance of gut dysbiosis and its link to hepatic impairment in long-term COVID patients. This letter underscores the importance of interdisciplinary collaboration and highlights the urgent need for conducting more research on GI manifestations of long COVID in order to define the mechanisms involved and possible pathways toward therapy.

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2025-04-30
2025-09-26

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References

  1. AlbrehtTJS Challenges to global health emerging from the COVID-19 pandemic.Sustainability2023159763310.3390/su15097633
     [Google Scholar]
  2. DesaiA.D. LavelleM. BoursiquotB.C. WanE.Y. Long-term complications of COVID-19.Am. J. Physiol. Cell Physiol.20223221C1C1110.1152/ajpcell.00375.202134817268
     [Google Scholar]
  3. ElbeltagiR. Al-BeltagiM. SaeedN.K. BediwyA.S. COVID-19-induced gastrointestinal autonomic dysfunction: A systematic review.World J. Clin. Cases202311225252527210.12998/wjcc.v11.i22.525237621592
     [Google Scholar]
  4. AlmullaAF ThipakornY ZhangY MaesM Elevated liver damage biomarkers in long COVID: A systematic review and meta-analysis.medRXiv20241810.1101/2024.10.18.24315698
     [Google Scholar]
  5. KariyawasamJ.C. JayarajahU. AbeysuriyaV. RizaR. SeneviratneS.L. Involvement of the liver in COVID-19: A systematic review.Am. J. Trop. Med. Hyg.202210641026104110.4269/ajtmh.21‑124035203056
     [Google Scholar]
  6. TsounisE.P. TriantosC. KonstantakisC. MarangosM. AssimakopoulosS.F. Intestinal barrier dysfunction as a key driver of severe COVID-19.World J. Virol.2023122689010.5501/wjv.v12.i2.6837033148
     [Google Scholar]
  7. ChenJ. VitettaL. The gut-liver axis in chronic liver disease associated with severe COVID-19.Eur. J. Gastroenterol. Hepatol.2021331S110334560696
     [Google Scholar]
  8. ZhangF. LauR.I. LiuQ. SuQ. ChanF.K.L. NgS.C. Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications.Nat. Rev. Gastroenterol. Hepatol.202320532333710.1038/s41575‑022‑00698‑436271144
     [Google Scholar]
  9. GolzardiM Hromić-JahjefendićA ŠutkovićJ AydinO Ünal-AydınP BećirevićT The aftermath of COVID-19: Exploring the long-term effects on organ systems.Biomedicines202412491310.3390/biomedicines12040913
     [Google Scholar]
  10. JeeyavudeenM.S. ChaudhariR. PappachanJ.M. FoudaS. Clinical implications of COVID-19 in patients with metabolic-associated fatty liver disease.World J. Gastroenterol.202329348750210.3748/wjg.v29.i3.48736688018
     [Google Scholar]
  11. BuchynskyiM. KamyshnaI. OksenychV. ZavidniukN. KamyshnyiA. The intersection of COVID-19 and metabolic-associated fatty liver disease: An overview of the current evidence.Viruses2023155107210.3390/v1505107237243158
     [Google Scholar]
  12. ZabetakisI. LordanR. NortonC. TsouprasA. COVID-19: The inflammation link and the role of nutrition in potential mitigation.Nutrients2020125146610.3390/nu1205146632438620
     [Google Scholar]
  13. AnY HeL XuX PiaoM WangB LiuT Gut microbiota in post-acute COVID-19 syndrome: not the end of the story.Front. Microbiol.202424150089010.3389/fmicb.2024.1500890
     [Google Scholar]
  14. DongZ. XiangB.J. JiangM. SunM. DaiC. The prevalence of gastrointestinal symptoms, abnormal liver function, digestive system disease, and liver disease in COVID-19 infection: A systematic review and meta-analysis.J. Clin. Gastroenterol.2021551677610.1097/MCG.000000000000142433116063
     [Google Scholar]
  15. WangB. ZhangL. WangY. DaiT. QinZ. ZhouF. ZhangL. Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions.Signal Transduct. Target. Ther.20227114310.1038/s41392‑022‑00986‑035487886
     [Google Scholar]
  16. FlahertyG.T. HessionP. LiewC.H. LimB.C.W. LeongT.K. LimV. SulaimanL.H. COVID-19 in adult patients with pre-existing chronic cardiac, respiratory and metabolic disease: a critical literature review with clinical recommendations.Trop. Dis. Travel Med. Vaccines2020611610.1186/s40794‑020‑00118‑y32868984
     [Google Scholar]
/content/journals/ijghd/10.2174/0126662906382468250417190958
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  • Article Type:     Editorial
Keyword(s): COVID-19; gut microbiota; gut-liver; immune-mediated mechanisms; long COVID; metabolic health

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