Umbilical IgE and Advanced Glycation Products in Association with Allergies in Childhood

Background: Little is known regarding the possibility of predicting allergy in genetically susceptible individuals. Objective: We endeavored to measure the levels of IgE, IgA and advanced glycation end products (AGEs) in the umbilical blood of newborns of allergic parents. Method: We collected two groups of newborns, the first group of 20 subjects with nonatopic parents, and the second with 20 subjects with a history of allergy in one or both parents. Results: Neonates born to parents with allergies had increased levels of AGEs in their umbilical cord blood. Conclusion: This causes increased oxidative stress and an increased probability of allergy and asthma in a child ´s future. We therefore propose that such children should be followed with the aim of lowering AGEs and IgE throughout life.