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- ISSN: 1871-5222
- E-ISSN: 1875-6115
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IL-17 and its Receptor Complex as Therapeutic Targets in Arthritis
- Source: Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Immunology, Endocrine and Metabolic Agents), Volume 8, Issue 3, Sep 2008, p. 247 - 251
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- 01 Sep 2008
Abstract
In addition to TNF and IL-1, IL-17 derived from Th17 cells is a leading cytokine target and has an established key role in adaptive and autoimmune disease such as rheumatoid arthritis (RA). A recent explosion in the literature in the last few years has lead to a renewal of interest in IL-17 as a key causative cytokine implicated in autoimmunity. This review will focus on IL-17 and its receptor as emerging therapeutic targets in RA.
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