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2000
Volume 25, Issue 4
  • ISSN: 1871-5265
  • E-ISSN: 2212-3989

Abstract

Background

COVID-19 patient hospitalization, particularly in intensive care units, exposes them to bacterial and fungi co-infections, which can have very serious consequences, including increased mortality. In addition, antibiotic resistance among pathogens is a hidden threat behind COVID-19.

Methods

In the period from 2020 September to 2021 August, bacterial isolates from COVID-19 patients admitted to the ICU of Sina Hospital in Hamadan, Iran, were collected and identified based on standard biochemical tests. COVID-19 cases were confirmed based on clinical symptoms, computed tomography, and polymerase chain reaction. Antimicrobial susceptibility tests were conducted using disc diffusion and broth microdilution methods.

Results

In total, 207 bacterial isolates were collected, with accounting for 69 (33.33%) and accounting for 59 (28.15%). The frequency and percentage of isolated bacteria were as species 28 (13.59%), 18 (8.73%), 15 (7.28%), 11 (5.33%), 3 (1.45%), species 3 (1.45%), and species 1 (0.48%). About 95.38% resistance to ceftazidime and cefotaxime and 92.31% resistance to ciprofloxacin and cefepime were found in isolates. isolates were 100% resistant to cefotaxime, ceftriaxone, and cefepime. About 22.22% resistance to vancomycin and 66.67% resistance to clindamycin, erythromycin, and cefoxitin were seen in isolates.

Conclusion

Knowledge of bacterial co-infections and their antibiotic resistance pattern in COVID-19 patients can help in choosing effective antibiotics for the treatment and prevention of antibiotic resistance.

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Investigating the Prevalence of Bacterial Infections in Patients with Coronavirus Disease 2019 Hospitalized in Intensive Care Unit and Determining their Antibiotic Resistance Patterns
Infect. Disord. Drug Targets 25, E18715265338445 (2025); https://doi.org/10.2174/0118715265338445241007092436
/content/journals/iddt/10.2174/0118715265338445241007092436
/content/journals/iddt/10.2174/0118715265338445241007092436
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  • Article Type:     Research Article
Keyword(s): antibiotic resistance; bacterial infections; co-infections; COVID-19; hospitalization; intensive care units

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