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- ISSN: 1871-5281
- E-ISSN: 2212-4055
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The Relationship Between Inflammation, Platelet Activation and Antiplatelet Resistance
- Source: Inflammation & Allergy-Drug Targets (Discontinued), Volume 9, Issue 5, Dec 2010, p. 364 - 381
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- 01 Dec 2010
Abstract
Even though there is a strong evidence suggestive of benefits and safety of dual (aspirin plus clopidogrel) antiplatelet therapy, decreased responsiveness or “resistance” to mono- and/or dual antiplatelet therapy has been described in association with an increased thrombotic risk. Various mechanisms contribute to antiplatelet resistance, with abundant production of inflammatory markers being of particular importance. The current review overviews implications of inflammation in antiplatelet resistance.
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