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- ISSN: 1872-3128
- E-ISSN: 1874-0758
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Differences in Lopinavir Plasma Concentrations Comparing Kaletra® Film Coated Tablets and Soft Gelatine Capsules That Result in Various Lipid Abnormalities
- Source: Drug Metabolism Letters, Volume 3, Issue 2, Apr 2009, p. 67 - 69
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- 01 Apr 2009
Abstract
Changes in lipids and lopinavir plasma concentrations were examined in 40 HIV-patients exposed to lopinavir/ ritonavir 400/100 mg BID, formulated as tablets and as capsules. Triglycerides and total/HDL-cholesterol ratio were significantly lower with tablets than with capsules. Lopinavir concentrations were higher with tablets than with capsules.
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