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- ISSN: 1872-3128
- E-ISSN: 1874-0758
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Pharmacokinetic and Pharmacodynamic Predictions of Novel Potential HIV-1 Integrase Inhibitors
- Source: Drug Metabolism Letters, Volume 2, Issue 4, Dec 2008, p. 256 - 260
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- 01 Dec 2008
Abstract
Virtual screening docking-based approach has been employed in order to select novel HIV-1 integrase (IN) potential inhibitors in large databases. Toxicity, metabolism and drug-like properties have been analyzed for the most promising compounds, using computational chemistry techniques. Results were compared and discussed with that obtained for a known HIV-1 (IN) inhibitor reported in the literature.
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