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- ISSN: 1872-3128
- E-ISSN: 1874-0758
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Microsome Biocolloids for Rapid Drug Metabolism and in hibition Assessment by LC-MS
- Source: Drug Metabolism Letters, Volume 2, Issue 3, Aug 2008, p. 158 - 162
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- 01 Aug 2008
Abstract
Rat liver microsomes attached to nanoparticles were used for LC-MS studies of CYP3A and 2E1 enzymes in metabolism of N -nitro so compounds.Using these biocolloids,turnover rates were measured within 2 min. Inhibitor IC 50 values for ketoconazole(KET) and 4-methylpyrazoie (4-MEP) were estimated.
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