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- ISSN: 1872-3128
- E-ISSN: 1874-0758
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Effects of Enzyme Sources on Midazolam 1-Hydroxylation Activity Catalyzed by Recombinant Cytochrome P450 3A4 in Combination with NADPH-Cytochrome P450 Reductase
- Source: Drug Metabolism Letters, Volume 2, Issue 3, Aug 2008, p. 190 - 192
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- 01 Aug 2008
Abstract
The influence of the enzyme source such as phospholipid and expression ratio of NADPHcytochrome P450 reductase on midazolam 1'-hydroxylation activity of cytochrome P450 3A4 was investigated in reconstituted systems and in membranes using bicistronic expressions. Preferable ratio of P450 reductase over human P450 3A4 would be a determinant factor for the drug metabolism studies.
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