- ISSN: 1872-3128
- E-ISSN: 1874-0758
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oa Long Term Treatment with Tetradecylthioacetic Acid Improves the Antioxidant Status in Obese Zucker (fa/fa) Rats
- Source: Drug Metabolism Letters, Volume 2, Issue 2, Apr 2008, p. 138 - 145
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- 01 Apr 2008
Abstract
Increased oxidative stress was observed in obese Zucker rats. Treatment of obese rats with tetradecylthioacetic acid for 12 weeks increased the H2O2-production, but decreased plasma malondialdehyde, changed the serum fatty acid profile, increased liver fatty acid binding protein mRNA, and lowered serum insulin, thereby enhancing the antioxidant defense system.
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