Full text loading...
- ISSN: 1872-3128
- E-ISSN: 1874-0758
-
Identification of a Novel Glutathione Conjugate of Diclofenac by LTQOrbitrap
- Source: Drug Metabolism Letters, Volume 2, Issue 1, Jan 2008, p. 35 - 40
-
- 01 Jan 2008
Abstract
High resolution accurate MS with an LTQ-Orbitrap identified two novel metabolites of diclofenac in rat bile and rat and human hepatocyte incubations: a benzyl-S-glutathione conjugate and 2-(2,6-dichlorophenylamino) benzoic acid. A mechanism for the bioactivation of diclofenac involving decarboxylation is proposed.
© Bentham Science Publishers