- ISSN: 1872-3128
- E-ISSN: 1874-0758
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oa Investigations Into the Drug-Drug Interaction Potential of Tapentadol in Human Liver Microsomes and Fresh Human Hepatocytes
- Source: Drug Metabolism Letters, Volume 2, Issue 1, Jan 2008, p. 67 - 75
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- 01 Jan 2008
Abstract
The new analgesic tapentadol was evaluated for induction and inhibition of several cytochrome P450 enzymes in vitro, and protein binding was assessed. It was concluded that no clinically relevant drug-drug interactions are likely to occur through either mechanism.
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