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- ISSN: 1872-3128
- E-ISSN: 1874-0758
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Metabolite Interference in Pharmacokinetic Studies
- Source: Drug Metabolism Letters, Volume 1, Issue 4, Dec 2007, p. 272 - 275
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- 01 Dec 2007
Abstract
Our policy of conducting biotransformation studies with extended chromatography prior to pharmacokinetic bioanalyses allowed us to quickly detect an unusual, cis/trans metabolite in rat plasma that was inseparable using a short chromatographic method. We caution investigators that short methods invite unknown isobaric metabolites to cause inaccuracies in plasma concentration measurements.
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