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- ISSN: 1872-3128
- E-ISSN: 1874-0758
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In Vitro Metabolism of Leflunomide by Mouse and Human Liver Microsomes
- Source: Drug Metabolism Letters, Volume 1, Issue 4, Dec 2007, p. 299 - 305
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- 01 Dec 2007
Abstract
Leflunomide was found to be metabolized predominantly to A77-1726 and two novel hydroxylated metabolites, M1 and M2, in microsomes while A77-1726 was only biotransformed to M1. M1 and M2 were proposed to be the hydroxylated α-cyanoenol form of A77-1726 and the hydroxylated 5 methyl-isoxazole form of leflunomide, respectively.
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