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- ISSN: 1872-3128
- E-ISSN: 1874-0758
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Application of In-Line Liquid Chromatography-Accurate Radioisotope Counting-Mass Spectrometry (LC-ARC-MS) to Evaluate Metabolic Profile of [3H]-Mefenamic Acid in Rat Plasma
- Source: Drug Metabolism Letters, Volume 1, Issue 3, Aug 2007, p. 179 - 188
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- 01 Aug 2007
Abstract
Profiling of rat plasma using a highly sensitive LC-ARC-MS technique showed that [3H] mefenamic acid was metabolized to several products, including a sulfate conjugate and a hydroxylated analogue as major metabolites. This technique of detecting low levels of radioactivity in plasma was superior to previously used methods, such as β-RAM detectors.
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