The Utility of Stable Cell Lines to Assess Species Differences in PXR Transactivation

Michael W. Sinz; Devin Pray; Judy Raucy

doi:10.2174/187231207780363561

ISSN: 1872-3128
E-ISSN: 1874-0758

The Utility of Stable Cell Lines to Assess Species Differences in PXR Transactivation
Authors: Michael W. Sinz¹, Devin Pray² and Judy Raucy³
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¹ 1989 Palomar Oaks Way, Suite B, Carlsbad, CA 92011, USA. ² 1989 Palomar Oaks Way, Suite B, Carlsbad, CA 92011, USA. ³ 1989 Palomar Oaks Way, Suite B, Carlsbad, CA 92011, USA.
Source: Drug Metabolism Letters, Volume 1, Issue 2, Apr 2007, p. 147 - 152
DOI: https://doi.org/10.2174/187231207780363561
- Available online: 01 Apr 2007

Abstract

A stable cell line was developed to assess activation of rat pregnane X receptor (rPXR) by xenobiotics. Characterization revealed that the greatest response occurred with dexamethasone (6-10 fold increase) while rifampicin failed to transactivate rPXR. Rodent PXR transactivation assays can be used to understand species differences in enzyme induction.

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2007-04-01

2025-10-11

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Article Type: Research Article

Keyword(s): CYP3A induction; high volume screening; Rat PXR; stable cells; toxicity

The Utility of Stable Cell Lines to Assess Species Differences in PXR Transactivation

Abstract

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